Ziprasidone alternative for olanzapine-induced hyperglycemia.

TO THE EDITOR: Among currently available atypical antipsychotic agents, clozapine and olanzapine are most often associated with clinically problematic weight gain and new-onset type 2 diabetes mellitus (1). Ziprasidone, a benzisothiazolylpiperazine, is a relatively new atypical antipsychotic that has been shown to be less likely to produce weight gain (2). We report on a patient with olanzapine-induced weight gain and type 2 diabetes whose blood glucose level returned to normal after he discontinued olanzapine and started treatment with ziprasidone.